The Asco meeting points to cell therapy as a gift for cancer treatment  Rio de Janeiro

The Asco meeting points to cell therapy as a gift for cancer treatment Rio de Janeiro

The Asco meeting is being held in Chicago, USAReproduction / Disgust

Posted on 6/6/2022 7:27 PM | Updated 6/6/2022 19:32

Rio – The meeting of the American Oncological Society (Asco) ends this Tuesday, in Chicago, in the United States. This event is known as the largest oncological event in the world and represents studies that bring together what has advanced in the treatment and diagnosis of various types of tumors. That year, cell therapy was identified as a gift for cancer treatment.

“This year’s edition shows that personalized medicine through immunotherapy and genetic testing is one of the paths to be followed in the fight against cancer,” said Daniel Herchenhron, scientific coordinator of Oncologia D’or, who is part of a delegation from 44 other networks. employees on site.

Cell therapy opens new horizons in the fight against tumors that are considered resistant. With the help of lymphocytes taken from the patient, cells are cultured in vitro who can specifically fight that person’s tumors. This new generation is promising for tumors such as melanoma, kidney and even pancreatic cancer.

“One of the presented cases brings good prospects, including pancreatic cancer, which is one of the most difficult to treat today. In this case, the treatment was carried out by genetic manipulation of cells from a common mutation in pancreatic cancer,” he added.

Another study noted the successful application of immunotherapy in patients with rectal cancer, without the need for more aggressive therapies and surgeries. “Some patients with colorectal tumors have mutations called microsatellite instability that are very sensitive to immunotherapy. In this case, the patients were treated with immunotherapy. In those whose disease disappeared, the use of chemotherapy, radio or even surgery was not necessary. Although initial, the data translate into a greater adjustment of treatment based on genetic studies and with certainly less toxicity, ”Herchenhorn reported.

This treatment is an example of medical advances that enable personalized realization from a patient’s DNA. It is an opportunity that opens new horizons for those who do not get a good response to traditional therapies. Herchenhorn points out that studies presented at ASCO show that this “personalized medicine” also allows for more accurate diagnoses, which help make decisions about the care needed.

One example is studies using ctDNA technology. With tumor fragments present in the bloodstream, called circulating tumor DNA, it is possible to more precisely design early detection of the tumor and its surgical recovery, contributing to monitoring. The technology provides more information to the oncologist to decide how to continue with the therapy.

According to Herchenhorn, this allows, for example, to better assess the chances of the tumor returning to its aggressiveness. Thus, the physician can avoid the use of more toxic treatments in lower risk cases. Studies conducted in colon cancer have shown that it is possible to indicate whether postoperative chemotherapy will be necessary based on the presence of circulating tumor DNA.

“Most importantly, these studies point to very promising pathways that can change the way we see the disease and how we will treat it in the near future. These are not the prospects for 30, 40 years “, concluded the oncologist.


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